血清假尿苷和尿假尿苷的相关性

The correlationship of serum psedouridine and urinary psedouridine

为了探讨血清假尿苷（ψ）和尿ψ的相关性，用高效液相色谱法（HPLC）在同样的色谱条件下检测50例正常人和175例恶性肿瘤患者血清ψ和尿ψ的含量．发现恶性肿瘤患者血清ψ和尿ψ水平明显升高，阳性检出率无明显差异，且二者呈高度相关（r＝0．66，P＜0．001）．认为随意尿中ψ的测定，可代替采血，值得临床推广应用。

To study the correlationship of serum psedouridine and urinary psedouridine. Under the same chro-matographic condition, high performance liquid chromatography assay was used to detect the concentration of serum psedouridine and urinary psedouridine in patients with malignant diseases and normal controls. The levels of serum and urinary pseudouridine in patient with malignant diseases were significantly higher than that in nor-mal controls. The relationships of serum psedouridine and urinary psedouridine were very well in patients with malignant diseases (r= 0. 66,P<0. 001). Only determination of pseudouridine in random urine was enough for the clinical application.