欧米诺汗印法对肿瘤多汗症的疗效观察

Observation on the Clinical Efficacy of Cancer-linked Hyperhidrosis with Neuropad Diagnostic Patches

目的观察肿瘤患者用止汗散治疗多汗症的疗效。方法将45例合并多汗症的肿瘤患者，随机分为实验组24例、对照组21例，分别予止汗散与安慰剂敷脐，采用欧米诺汗印法诊断膏贴（Neuropad）观察用药前后变色时间，并根据中医常见症状、体征分级积分表观察用药前后证候以及KPS的变化。结果实验组用药前后汗印法变色时间分别为（14．45±3．91）min及（19．51±5．30）min；对照组用药后为（15．68±7．17）min，实验组用药前后及与对照组比较差异均有统计学意义（P〈0．05）；中医证候：用药前后自汗、盗汗、口干、手足心热、身热、畏寒肢冷等症状明显改善。结论运用欧米诺诊断膏贴的变色原理，评价止汗散敷脐治疗后多汗症的缓解程度更为客观。

Objective To observe the clinical efficacy of applying Sweat Reduction Formula （SRF） externally in the treatment of cancer-linked hyperhidrosis. Methods 45 tumor patients, who exhibited excessive perspiration, were selected and recruited randomly into an experimental group （Sweat Reduction Formula group） with 24 patients in it and a control group （Placebo group） with 21 patients in it. The experimental group was treated with SRF and the control group was administrated with placebo. Neuropad diagnostic patches were used to observe the period of time that required for any visual changes in color before and after medication. These observations were then matched with the commonly seen signs and symptoms scoring table, to evaluate the changes of symptoms and KPS. Results The color changing time of the experimental group was 14.45 _＋ 3.91 min. and 19.51 ±5.30 min. before and after medications respectively. And the changing time in the control group was 13.49±4.96 min. After medication. The results were highly significant with P〈0.05. There were also different levels of significant improvements in terms of spontaneous perspiration, night sweating, dry mouth, feverish sensation over hand-foot centers and body, aversion to cold etc after the treatment in the experimental group. Conclusion It would be more objective to evaluate the clinical efficacy of applying SRF on navel to treat cancer-linked hyperhidrosis with neuropad diagnostic patches.