中医辨证防治化疗药物肝毒性60例临床观察与思考

TCM Drug Prevention and Treatment of Chemotherapy 60 Cases of Liver Toxicity of Clinical Observation and Thinking

目的:观察评价中药防治化疗后药物肝损伤。方法:对60例化疗肿瘤患者随机分为两组:西药组、中药组。西药组予硫普罗宁、还原型谷胱甘肽保肝用药14天,中药组按毒热炽盛、湿毒内蕴、肝郁脾虚、阴虚四型施治用药14天观察并统计分析。结果:两组间生活质量差异有显著性(P<0.05);化疗后消化道副反应治疗组与对照组比较差异有显著性(P<0.05);化疗第14天查肝功能,治疗组和对照组较化疗前肝功能无差异(P>0.05),化疗第28天查肝功能,对照组ALT、AST、ALP、TBIL与化疗前治疗组对比均有差异(P<0.05),治疗组与化疗前肝功能对比无差异(P>0.05)。结论:中医辨证用药可以防治化疗药物肝毒性,减轻患者的消化道副反应,保证化疗的顺利进行,提高治疗效果。

Objective：To observing and analyzing the prevention and treatment of chemotherapy medicine liver damage effects of drugs. Methods：60 cases of chemotherapy for cancer patients were randomly divided into two groups： group of western medicine, Chinese medicine group. Tiopronin to the WM group, the liver glutathione administration for 14 days, according to the Chinese Medicines Board Syndrome flourishing drug fever,Shiduqing intrinsic, stagnation of liver deficiency, IV deficiency within 14 days of drug treatment and observation statistical analysis. Results ： Quality of life differences between the two groups was significant（P 〈0. 05 ） ;gastrointestinal side effects after chemotherapy treatment group compared with the control group there was a significant difference （P 〈 0. 05 ） ;chemotherapy in the first 14 days of check liver function, the treatment group and than the control group,liver function before chemotherapy is no difference（P 〉 0. 05）. Chemotherapy in the first 28 days of check liver function, the control group ALT, AST, ALP, TBIL and before chemotherapy, the treatment group differences were compared（ P 〈 0. 05 ） ;the treatment group and comparison of liver function before chemotherapy is no difference （P 〉 0.05）. Conclusion：TCM drugs can be prevented liver toxicity of chemotherapy drugs and reduce side effects in patients with digestive tract, improve the quality of life of patients and ensure the smooth progress of chemotherapy to improve treatment.