肝硬变门脉高压形成中血浆TNF水平的变化

Plasma TNF levels during the formation of liver cirrhosis and portal hypertension in rats

目的观察ＳＤ大鼠肝硬变门脉高压形成过程中ＴＮＦ浓度与肝损伤的关系．方法采用放射免疫测定法．团体ｔ检验．结果ＴＮＦ水平（ｎｇ／Ｌ）在早（１２２±０２６）中（１２１±０２３）晚（１２３±０１７）三期肝硬变中与正常组（０９７±０２３）相比明显升高（Ｐ＜００５）；与门脉压力变化无明显相关．结论ＴＮＦ水平升高，加重了肝脏损伤和肝纤维化病变，与门脉压力变化无关．

IM Abstract:To evaluate the relationship between the level of TNF and liver damage in the development of liver cirrhosis and portal hypertension in cirrhotic rats.METHODS Radioimmunoassy was used. RESULTS The level of TNF (ng/L) was significantly elevated in early (1.22±0.26), middle (1.21±0.23) and late (1.23±0.17) stage of liver cirrhosis as compared with that in control (0.97±0.23) group (P<0.05).CONCLUSION The liver damage and liver cirrhosis were worsened with elevated TNF levels, and is not related to the changes of portal pressure.