消化性溃疡及糜烂性胃炎患者前列腺素及血栓素与幽门螺杆菌的关系

Relationship among 6ketoPGF-1α, TXB-2 and H.pylori in patients with peptic ulcer and erosive gastritis

目的探讨消化性溃疡及糜烂性胃炎与前列腺素、血栓素及幽门螺杆菌的关系．方法用放免技术，测定消化性溃疡（ｎ＝５３）、糜烂性胃炎（ｎ＝５５）患者及正常人（ｎ＝５４）血浆中前列腺素（６ｋｅｔｏＰＧＦ１α）、血栓素（ＴＸＢ２）的含量，并胃粘膜活检组织学查幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）．结果溃疡组及糜烂性胃炎组ＴＸＢ２含量及ＴＸＢ２／６ｋｅｔｏＰＧＦ１α的比值均明显高于对照组（Ｐ＜００１），两组的６ｋｅｔｏＰＧＦ１α的含量与对照组无差异（Ｐ＞００５）．两组患者中Ｈｐ（＋）与Ｈｐ（－）之间的６ｋｅｔｏＰＧＦ１α，ＴＸＢ２的含量及ＴＸＢ２／６ｋｅｔｏＰＧＦ１α的比值均无差异（Ｐ＞００５）．结论ＴＸＡ２与ＰＧＩ２失衡可能与溃疡的发病密切相关。

IM To explore the relationship among 6ketoPGF-1α, TXB-2 and H.pylori in peptic ulcer and erosive gastritis.METHODS Serum levels of 6ketoPGF-1α and TXB-2 were measured by using radioimmunoassay in patients with peptic ulcer (n=53), erosive gastritis (n=55), and normal controls (n=54). All patients were tested by histology to determine whether he (she) was infected with H.pylori.RESULTS The serum TXB2 level and the ratio of TXB-2/6ketoPGF-1α were significantly higher in peptic ulcer and erosive gastritis than that in normal subjects. There was no obvious difference among the three groups in 6ketoPGF-1α. There was also no obvious difference in TXB-2, 6ketoPGF-1α and the ratio of TXB-2/6ketoPGF-1α between the groups of Hp(+) and of Hp(-).CONCLUSION The imbalance of TXA-2PGI-2 is involved in the pathogenesis of peptic ulcer, and there is no relationship between H.pylori and prostaglandin.