核黄素对心绞痛治疗作用的临床研究

The Therapeutic Efficacy of Riboflavin on Angina Pectoris

目的观察核黄素对心绞痛的临床疗效。方法７８例劳力性心绞痛患者随机分成Ｂ组（ｎ＝２８，核黄素７５ｍｇ·ｄ－１，ｐｏ）、Ｉ组（ｎ＝２２，硝酸异山梨（醇）酯１５ｍｇ·ｄ－１，ｐｏ）和Ｃ组（ｎ＝２８，安慰剂，ｐｏ），各组均连续服药４Ｗ。用药前后检测静息心电图（ＥＫＧ）、血小板聚集性（ＰＡＧ）和血清丙二醛（ＭＤＡ）含量，并于用药前、用药第２Ｗ、用药第４Ｗ末记录心绞痛症状。结果核黄素对ＥＫＧ和心绞痛症状的疗效与硝酸异山梨（醇）酯相比无明显差异，但显著高于Ｃ组（Ｐ＜０．０１，Ｐ＜０．０１）。结论核黄素能有效治疗心绞痛。

Aim\ The therapeutic efficacy of riboflavin (RBF) on angina was evaluated.\ Methods\ 78 cases of angina were divided into B group ( n =28,RBF 75 mg·d -1 ×30,po). Group I( n =22, isosorbide dinitrate 15 mg·d -1 ×30,po)and C group ( n =28, placebo for 30 days) . EKG 、 platelet aggregation in blood and serum malondiadehyde (MDA) content were examined before and after drug. The clinical manifestations of angina were recorded before and after treatment two weeks or four weeks.\ Results\ The total effective rate of EKG and therapeutic effect of angina was significantly higher in B group than that in C group ( P<0.01,P <0.01,respectively.) But no significant difference was found between B and I group.\ Conclusion\ Riboflavin is an effective drug for angina and it's mechanism may be related to antiplatelet aggregation and inhibiting lipid peroxidation in patient with angina.