高血压患者血浆一氧化氮含量与动态血压的关系

The Relationship Between Plasma Nitric oxide and Ambulatory Blood Pressure in Hypertension

目的探讨原发性高血压患者血浆一氧化氮含量变化及其与２４小时动态血压值的相关性。方法５８例原发性高血压患者，平均年龄６０．２±１１．７岁，男性３０例，女性２８例，用比色法测定血浆硝酸根含量，并用２４小时动态血压仪测量动态血压。结果高血压患者血浆硝酸根含量（１．２１±０．４３ｎｍｏｌ／ｍｌ）明显低于正常人（１．４６±０．２３ｎｍｏｌ／ｍｌ），并与疾病的严重程度相平行，相关分析显示血浆硝酸根含量与２４小时动态血压值呈负相关。结论一氧化氮在高血压病的发生。

Aim\ To survey the changes of plasma nitric oxide(NO) and the relationship between NO and ambulatory blood pressure( ABP) in hypertension.\ Methods\ 58 hypertensive patients, average age 60.2 years, male 30 cases and female 28 cases,were examined the plasma NO by colorimetric method and blood pressure by 24 hours ambulatory blood pressure monitoring(ABPM).\ Results\ The nitrite level(1.21± 0. 43 nmol/ml) was reduced in hypertensive patients. The change was correlated to the severity of disease. Correlation anlaysis showed that nitrite level correlated negatively to the parameters of ABPM.\ Conclusion\ Reduced NO prodution may be an important cause of the hyertension.