高血压患者硝苯地平治疗前后血浆内皮素和降钙素基因相关肽的变化

Changes of Plasma Eudothelin and Calcitonin Gene Related Peptide in Hypertension treated with Nifedipine

目的观察硝苯地平降压治疗对血浆内皮素（ＥＴ）和降钙素基因相关肽（ＣＧＲＰ）水平的影响。方法３１例原发性高血压（ＥＨ）患者口服硝苯地平控释片４０ｍｇ／ｄ×１４，用放免法直接测定治疗前后的血浆ＥＴ和ＣＧＲＰ水平。结果ＥＨ患者血浆ＥＴ水平明显高于对照组（８５．６±２１．０ｖｓ４２．１±２０．３ｐｇ／ｍｌ，Ｐ＜０．００１）；ＣＧＲＰ水平明显低于对照组（２３．０±８．１ｖｓ５５．４±１７．８ｐｇ／ｍｌ，Ｐ＜０．００１）。舒张压与ＥＴ水平呈正相关（ｒ＝０．５３０２，Ｐ＜０．００５），ＥＴ与ＣＧＲＰ呈弱的负相关（ｒ＝０．３７０７，Ｐ＜０．００５）。治疗后，血压和ＥＴ水平明显下降（Ｐ均＜０．００１），ＣＧＲＰ水平显著增高（Ｐ＜０．００１）。结论硝苯地平是一种有效的降压药，它可通过调节ＥＨ时多种血管活性多肽之间的平衡关系。

Aim\ To determine plasma levels of endothelin( ET) and calcitonin gene- related peptide( CGRP) before and after the antihypertensive treatment with nifedipine in essential hypertensive subjects.\ Methods\ 31 patients with essential hypertension were given slow released nifedipine 40 mg once daily. Plasma levels of ET and CGRP were measured by radioimmunoassay before and after 2 weeks of the treatment with nifedipine.\ Results\ Before the treatment , essential hypertensive subjects had higher level of ET(85.6±21.0 vs 42.1±20.3 pg/ml, P <0.001) and lower level of CGRP(23.0±8.1 vs 55.4±17.8 pg/ml, P <0. 005) as compared with those in control subjects. Diastolic pressure correlated positively with plasma level of ET( r=0.5302, P <0.005) . After the treatment, plasma level of ET decreased and plasma level of CGRP increased significantly( P<0.001 and P <0.001,respectively).\ Conclusion\ These results suggest that plasma ET and CGRP may be involved in pathogenesis of essential hypertension, Nifedipine has an important role in protecting organs via the regulation of plasma levels of ET and CGRP.