宫颈癌新辅助化疗34例临床疗效观察

The clinical therapeutic effectiveness of neoadjuvant chemotherapy for 34 patients with cervical cancer.

目的探讨新辅助化疗在Ib2-Ⅱb期宫颈癌辅助治疗中的临床效果。方法选择2003年5月-2008年4月收住的34例Ib2-Ⅱb期宫颈癌患者，采用化疗方案行1-2个疗程的静脉化疗之后全部行宫颈癌根治术，观察其近期疗效。结果化疗有效率为76.4％。手术切除率达94.1％，化疗效果与期别无关，而与病理类型有关。鳞癌的有效率明显高于腺癌（P〈0.05）。结论宫颈癌新辅助化疗是安全有效的，可以提高宫颈癌的近期疗效，其作为治疗宫颈癌的一种新手段，具有重要的临床意义。

Objective To investigate the clinical therapeutic effectiveness of neoadjuvant chemotherapy for cervical cancer in stages Ⅰb2-Ⅱb. Methods Thirty-four patients with cervical cancer in stages Ⅰb2 to Ⅱb were chosen in our hospital from May 2003 to April 2008. All patients were treated with 1-2 courses of venous chemotherapy, and then underwent radical sur-gery. Results The effective rate of chemotherapy was 76.4%. The resection rate of surgery after chemotherapy was 94.1%. And the therapeutic effectiveness was not associated with clinical staging, but with histological types. The effective rate of chemotherapy in squamous cell cancer was significantly higher than that in adenocarcinoma （P〈0.05）. Conclusion Neoadjuvant chemotherapy of cervical cancer is safe and effective, and can increase short term effectiveness. As a new and effective method for treating cervical cancer, it is of great importance in clinical practice.