卡托普利治疗对SHR大鼠遗传血压、左心室肥厚及心肌胶原的影响

Effects of Low Dose Captopril Treatment on Inherent Blood Pressure,Left Ventricular Hypertrophy and Myocardium Collagen in SHR

目的探讨卡托普利对自发性高血压大鼠（ＳＨＲ）的血压及左心室肥厚的影响。方法选用一组ＳＨＲ（Ｆ０），从交配之日起每天给卡托普利（２０ｍｇ／ｋｇ），其子代（Ｆ１）持续治疗到１６周时分为２组。第一组Ｆ１ａ在交配时继续用药治疗；第二组Ｆ１ｂ交配时停药。第二代两组小鼠（Ｆ２）出生后，Ｆ２ａ继续用药治疗到１６周停药；Ｆ２ｂ不用药治疗。分别观察其血压，左心室重量（ＬＶＭ），左心室重量与体重比（ＬＶＭ／ＢＷ）及测定左心室羟脯氨酸浓度和计算机图像分析心肌胶原的含量。结果发现在停药前动物血压处于较低的水平，但明显高于ＷＫＹ；而停药后血压明显回升到接近ＳＨＲ的水平。Ｆ２ａ表现基本一致；而Ｆ２ｂ的血压与对照组ＳＨＲ一样，明显高于Ｆ２ａ组。心肌内羟脯氨酸浓度及胶原含量，在Ｆ２ａ明显较ＳＨＲ和Ｆ２ｂ低，接近ＷＫＹ水平。结论卡托普利治疗并不能防止ＳＨＲ的高血压的遗传发展，但可以减低左心室肥厚。

Aim\ To explore the influence of captopril treatment on inherent blood pressure, left ventricular hypertrophy and myocardium collagen in spontaneous hypertensive rat(SHR).\ Methods\ SHR(F 0) were given captopril(20 mg/kg·d -1 ) in the age of 16 weeks after mating and throughout pregnency and lactational period. Their offspring(F 1) were divided into two groups(F 1a , continuous medication,F 1b non medication). F 1a received the same drug administration protocal of F 0 until the delivery of F 2. F 2 were also divided into 2 groups with F 2a being treated with captopril and F 2b of nontreated.\ The treating program in F 2 were the same as that was applied in F 0 and F 1.\ All animals were killed at the fortieth weeks.\ The body weight,blood press,heart rate,ventricular hypertrophy and myocardium collagen were examined.\ Results\ The SBP of captopril treated F 0 and F 1 was significantly lower than that of control SHR, but SBP resumed slowly and markedly as soon as discontinuation of the treatment and approched the level of control SHR.\ Likewise, the treated F 2a showed a similar courses of the development of SBP as that of treated F 0 and F 1.\ However,the LVM,LVM/BW and the content of hydroxyproline in myocardium in F 2a were significantly lower than that in F 2b even thier SBP reached the same level of control SHR.\ Conclusion\ The low dose captopril cannot reduce the hypertension in SHR after 2 generation treatment.\ However,the left ventricular hypertrophy, especially the content of myocardium collagen was significantly reduced. A dissociation between left ventricular hypertrophy,fibrosis and high blood pressure was found.