顺尔宁预防婴幼儿毛细支气管炎后再发喘息的临床研究

Clinical Research of Singulair Prevention for Wheezing Infants and Young Children after Brochiolitis

目的探讨顺尔宁预防婴幼儿毛细支气管炎后反复喘息的临床效果。方法92例毛细支气管炎急性期控制后患儿随机分为干预组(47例)和对照组(45例),全部病例给予常规治疗,同时干预组给予顺尔宁干预治疗,疗程3个月。对照组则不用任何药物预防。随访2年。测定血清总IgE浓度和嗜酸性粒细胞计数,观察喘息反复发作情况。结果发生反复喘息组血清总IgE浓度和嗜酸性粒细胞计数显著高于未再发喘息组(P<0.05);干预组第1年和第2年反复喘息发作人数和总平均发作次数均显著低于对照组(P<0.05)。结论采用顺尔宁预防婴幼儿毛细支气管炎后再发喘息临床效果明显,可以降低喘息的发作次数和哮喘的发生率,值得临床推广应用。

Objective To investigate the clinical effect of singulair prevention for wheezing infants and young children after brochioIitis.Methods 92 cases of infants and young children with acute phase Of bronchiolitis after control were randomly divided into intervention group（47 cases） and control group（45 cases）,all patients were given conventional treatment, while the intervention group was given treatment by singulair, treatment for 3 months, the control group without any drug prevention, follow--up for 2 years. The serum total IgE and eosinophil count were determined, the recurrent wheezing was observed. Results The serum total IgE and eosinophil count of recurrent wheezing group was significantly higher than that of the no-recurrent wheezing group（P 〈0.05）1 the recurrent wheezing cases and the total average number of intervention group in the 1 year and 2 years were significantly lower than that of the control group（P〈0.05）.Conclusion The clinical effect of singulair prevention for wheezing infants and young children after brochiolitis is significant. Singulair can reduce the breathing frequency and the incidence of asthma, it is worth clinical application.