TAO患者红细胞免疫功能与SOD和LPO关系的研究

STUDY ON THE RELATIONSHIP BETWWEN IMMUNOLOGIC FUNCTION OF RED CELLS AND SOD AND LPO IN PATIENTS

目的探讨血栓闭塞性脉管炎ＴＡＯ的发病机制，为临床诊断、治疗提供依据。方法应用红细胞葡萄球菌蛋白Ａ混和花环试验对７６例ＴＡＯ病人和５５名正常人外周血进行了红细胞免疫功能测定，同时对其ＳＯＤ和ＬＰＯ的含量进行了检测。结果急性期ＴＡＯ病人和正常对照相比较，ＲＢＣＣ３ｂＲＲ明显降低（Ｐ＜００１），而ＲＢＣ—ＩＣＲＲ则明显升高（Ｐ＜００１），而稳定期病人与正常对照无显著变化，ＴＡＯ患者活动期和稳定期ＳＯＤ含量均降低，血清ＬＰＯ浓度均升高。结论ＴＡＯ患者存在着红细胞免疫功能异常，同时体内抗氧化能力降低、脂质过氧化物损伤也导致了红细胞免疫调节功能异常。

Objective To explore the pathogenesis of TAO in order to provide basis for clinical diagnosis and treatment Method Immunologic function of red cells in peripheral blood from 76 cases of TAO and 55 normal people was detected by mixed rosette test of RBC staphylococcal protein A,and the contents of SOD and LPO were also detected Results When the patients were at stage ,activity of RBC c3b receptor was remarkably reduced (P<0.01)while the rate of RBC immune complex rosette was increased (P<0.01).However,there was no obvious difference between the patients at stable stage and normal people .The level of SOD in active and stable stage was decreased while LPO level increased Conclusion The immunologic function of red cells in patients with TAO was abnormal ,which may be resulted from the reduction of antioxide ability and injuried LPO.