Graves病患者血清β_2微球蛋白测定的意义

THE SIGHIFICANCE OF SERUM β_2MICROGLOBULIN(Sβ2M) IN GRAVES DISEASES

目的探讨Ｇｒａｖｅｓ病患者血清β２Ｍ测定的意义。方法用放免法测定６１例Ｇｒａｖｅｓ病患者治疗前后血清Ｔ３、Ｔ４与β２Ｍ含量，并与健康对照组５６例对比。结果治疗前组血清Ｔ３、Ｔ４与β２Ｍ均显著高于健康对照组（Ｐ＜０００１），治疗后Ｔ３、Ｔ４及与β２Ｍ也同步降至正常，与治疗前组比Ｐ＜０００１。结论测定血清β２Ｍ是了解Ｇｒａｖｅｓ病免疫学状况、观察疗效、判断预后、估计复发的一个简便而有价值的检验方法。

Objective To investigate the clinical significance of Sβ2M in Graves diseases(GD).Method The contents of Sβ2Μ、T3 and T4 was measured by RIA method in 61 cases of GD before and after antigoiter therapy,and compared with these of 56 cases of healthy controls.Results T3 and T4 and Sβ2Μ were synchronously increased in the pretherapeutic group and also synchronously decreased to normal ranges in posttherapeutic group.Conclusion Sβ2Μ measurement is a simple、conveiniant and valuable lab method for evaluating the immunological condition、therapeutic effectiveness and prognosis in GD.