胆囊癌患者血清及胆汁瘦素水平测定及相关性分析

Study of the relationship between leptin level in serum and bile in patients with gallbladder carcinoma

目的测定并分析患者血清及胆汁瘦素(Leptin)水平与胆囊癌的相互关系。方法选取2008年7月12日～2009年6月23日我院收治的胆囊癌病例10例、胆囊息肉患者10例及胆囊结石患者10例,应用放射免疫方法测定并分析其血清及胆汁中的Leptin水平。结果1.胆囊癌组血清Leptin水平显著高于胆囊息肉组。2.胆囊癌组血清Leptin水平显著高于胆囊结石组。3.胆囊结石组血清Leptin水平显著高于胆囊息肉组。4.胆囊癌组胆汁Leptin水平显著高于胆囊息肉组。5.胆囊癌组胆汁Leptin水平显著高于胆囊结石组。6.胆囊结石组胆汁Leptin水平显著高于胆囊息肉组。7.胆囊息肉组、胆囊结石组及胆囊癌组的胆汁瘦素水平都显著高于血清瘦素水平。结论瘦素与胆囊癌的形成可能有关,可能成为临床预测胆囊癌的一个指标。

Objective To detect and analyze the relationship between serum and bile leptin in patients with gallbladder carcinoma. Methods The levels of the serum and bile leptin of 10 gallbladder polyp patients, 10 cholecystolithiasis patients and 10 gallbladder carcinoma patients were detected with radioimmunoassay respectively. Re-suits 1. leptin level in serum of gallbladder carcinoma group was significant higher than gallbladder polyp group. 2. leptin level in serum of gallbladder carcinoma group was significant higher than cholecystolithiasis group. 3. leptin level in serum of cholecystolithiasis group was significant higher than gallbladder polyp group. 4. leptin level in bile of gallbladder carcinoma group was significant higher than gallbladder polyp group. 5. leptin level in serum of gallbladder carcinoma group was significant higher than cholecystolithiasis group. 6. leptin level in serum of cholecystolithiasis group was significant higher than gallbladder polyp group. 7. Bile leptin levels were significantly higher than serum leptin levels in gallbladder carcinoma group,gallbladder polyp group and cholecystolithiasis group. Conclusion Leptin may play an important role in pathogenesy of carcinoma of gallbladder, and it would probably be one index of clinical prediction of carcinoma of gallbladder.