L-2-(N-叔丁氧酰基)-3',4'-二甲氧基苯丙氨酸乙酯的合成

An efficient method for the synthesis of L-2-(N-Boc)-3',4'-dimethoxyphenylalanine ethyl ester

目的:改进L-2-(N-叔丁氧酰基)-3',4'-二甲氧基苯丙氨酸乙酯的合成工艺。方法:以左旋多巴为起始原料,采用"半分离纯化"的制备方法进行合成,并对处理工艺进行优化。结果:通过此法制备步骤简单,后处理容易,可有效减少原料及中间体的氧化程度。总收率达到45.4%。结论:这是一种易于操作、适合规模化生产的制备工艺。

Objective： To improve the synthetic process of L-2-（N-Boc）-3′,4′-dimethoxyphenylalanine ethyl ester. Methods：The target molecular was prepared from L-DOPA by using a ＂half-purified＂ method. The disposition technics were optimized. Results： The synthetic process offers a simple, easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate. The overall yield is 45.4%. Conclusion ：The optimized synthetic process is easy to operate and suitable for large-scale production.