摘要
目的:考察葛根黄酮对衰老模型小鼠抗氧化能力的影响。方法:用D-半乳糖制备衰老模型小鼠,分为正常对照组、模型组、阳性对照组、高、低剂量组,检测各组小鼠血清丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH—PX)水平变化。结果:葛根黄酮能显著降低衰老小鼠血清MDA水平,同时可提高SOD和GSH—PX活力水平。结论:葛根黄酮对亚急性衰老模型小鼠具有抗氧化作用。
Objective： To study the effect of Puerarin flavonoid on anti-oxidative in subcute aging mice model. Methods：The aged mice were induced by ip D（＋）-galactose for 49 d. Malondialdehyde （MDA）, superoxide dismutase（SOD）, and glutathione peroxidase（GSH-PX） in serum were determined. Results： Puerarin flavonoid can inhibit MDA level in serum significantly, increase the ratio of SOD activity to GSH-PX activity. Conclusion： Flanone from Puerarea has good anti-oxidative effect.
出处
《四川生理科学杂志》
2009年第4期145-146,共2页
Sichuan Journal of Physiological Sciences
基金
山西省留学回国人员基金资助项目(200889)
关键词
葛根黄酮
抗氧化
亚急性衰老模型
Puerarin flavonoid
Anti-oxidative effect
Subacute aging model
