不同年龄组的系统性红斑狼疮临床及血清学特征分析

Analysis of clinical and serologic features in different onset age of patients with SLE.

目的：为探讨系统性红斑狼疮（ＳＬＥ）的发病机理，更好地指导临床治疗。方法：我们分析比较了发病年龄＜１８岁、１８～３５岁之间及＞３５岁三个不同年龄组的ＳＬＥ患者临床及血清学特征的异同，并与美国黑人及美国白人ＳＬＥ相比较。结果：发现ＳＬＥ患者中肾脏损害与发病年龄有关，最年轻的病人组有最高的肾损害发生率。随着发病年龄的增大，中枢神经系统及血液系统受累频率增高，但均无显著差异。与美国黑人患者相似，中国汉族ＳＬＥ患者抗体频率均较美国白人高。结论：提示对于发病年龄较小的ＳＬＥ患者要谨防肾脏损害的发生，中国汉族ＳＬＥ自身抗体的分布与美国黑人患者较接近，而与美国白人ＳＬＥ有较大的差异。

Objective:To study the pathogenesis of SLE,improve clinical treatment better.Method:We analysed the clinical and serologic characteristics of three different groups of SLE patients with onset age at <15 years,15～35 yrars and>35 years,and compared with american black and white SLE patients.Results:Renal involvement was related to age at disease onset,the highest incidence of involvement seen in the youngest group.There was a trend,however not significant,toward more hematologic and nuropsychiatric involvement with elder patients at disease onset.Similar to black SLE patients,anti Sm and anti RNP antibodies were found more frequently in Han's SLE patients than in whites.Conclusion:We should prevent renal involvement in those younger patients at disease onset.The distribution of autoantibodies in Han's patients was similar to black patients,but different to white patients.