斑秃患者甲襞微循环改变及实验性治疗

The Changes of Nailfold Microcirculation in Alopecia Areata and Experimental Therapy

目的；探讨斑秃病人甲襞微循环的改变及实验性治疗效果。方法：对门诊斑秃病人进行甲襞微循环观测，以正常人作对照。结果：32例斑秃病人甲襞微循环的清晰度稍有下降，异形管襻比正常人增多（P＜0．05）。红细胞有轻、中度聚集，血流速度减慢，部分病人有轻度襻周渗出，少数病人有襻顶出血。甲襞汗腺导管多于正常人，全秃病人又比一般斑秃病人多（P＜0．001）。654－2促进了毛发生长，且新生毛发不易脱落。结论：斑秃病人存在微循环障碍。654－2对治疗斑秃是有意义的。

Purpose:To observe the changes of nailfold microcirculation and the effect of anisodamine on the patients. Method:The nail fold microcirculation of 32 cases with alopecia areata was observed by microcir-culatory micrography. Result:Compared with control subjects,the patients with alopecia areata have obvious microcirculatory changes in their nail fold. The visibility was reduced slightly,the number of turtuosity loops increased (P<0.05), the number of nail foId sweat ducts increased in patients with alopecia totalis (P<0.001) The blood velocity is reduced and the mild to moderate degree of erythrocyte aggregation was ob-served. The petechias on loop tips were found in some cases. The microcirculatory states improved in alopecia after anisodanmine was given,with improvement of sleeping and growth of neo-hair. Conclusion:The patients with alopecia areata have microcircuatory dysfunction. The anisodanmine may have therapeutic effects on the alopeccia areata.