龟芪散及其拆方对免疫抑制小鼠IL-2产生及其基因转录的影响

Effects of Guiqi Powder and Its Simplified Formula on IL-2 mRNA andProtein Expression Level of Immunosuppressed Mice

龟芪散及其拆方可明显增强Ｃｙ所致免疫受损小鼠Ｔ淋巴细胞的增殖；提高Ｌ３Ｔ＋４细胞数量及Ｌ３Ｔ＋４／Ｌｙｔ＋２细胞比率；促进脾细胞ＩＬ－２ｍＲＮＡ转录和ＩＬ－２产生。以全方效果最佳，亦好于ＰＳＰ。但对正常小鼠无明显影响。

Guiqi powder as a whole and its simplified formulae could promote significantly the proliferation of T lymphocytes,increase L3T+4 cells counts raise ratio of L3T+4/Lyt+2 cells and enhance spleen cells IL-2 mRNA and protein expression level in immunosuppressed mice caused by cyclophosphamide.The original Guiqi powder as a whole was more potent than its simplified formula as well as PSP.However it showed no effects in normal mice.