黄芪生脉颗粒剂对小型猪实验性心肌缺血时的影响

Effect of Radix Astragali Shengmai Granules on Experimental Myocardial Ischemia in Pigling

采用健康小型猪结扎冠状动脉左前降支造成心肌缺血模型，以检测平均动脉压（ＭＡＰ）、左室收缩峰压（ＬＶＳＰ）、左室舒张终末压（ＬＶＥＤＰ）、心率（ＨＲ）等指标观察灌服黄芪生脉颗粒剂后对小型猪实验性心肌缺血的影响。并采用ＴＴＣ染色心肌片，求得梗塞心肌占心室重量的百分比。结果表明，该制剂可明显减轻心肌缺血的程度和范围，减少缺血性心律失常的发生。

The myocardial ischemia model was produced by ligating descending branches of left coronary artery anterior in anesthetized pigling. Using the methods of TTC ink double staining and the ratio of the myocardial infarction tissue to the whole ventricle was assessed. The effect of radix astragali Shengmai Granules on the experimental myocardial ischemia was evaluated by measurring the mean artery pressure (MAP), the left ventricular contracture pressure(LVSP), the left ventricular end diastolic pressure(LVEDP) and the heart rate(HR) etc. The results showed that the radix astragali Shengmai Granules could signifcantly reduced the myocardial ischemia limits and degree inhibited obviously the ocurrence of arrhythmia, improve signifcantly the electrophysiocal stability in the myocardial alls.