焦虑症患者单光子发射计算机断层研究

A functional neuroimaging study on anxiety patients with SPECT.

目的探讨焦虑障碍与局部脑功能改变的关系。方法对５３例焦虑症患者（分治疗组与未治疗组）和１５名正常对照者应用单光子发射计算机断层摄影（ＳＰＥＣＴ）测定局部脑血流（ｒＣＢＦ）灌注。结果焦虑症患者ｒＣＢＦ灌注异常率为９２５％（４９／５３），与对照组比较，治疗组、未治疗组病人的双侧额叶及颞叶ｒＣＢＦ灌注均有极显著下降，治疗组的左侧基底节下降也有显著差异。结论焦虑症患者额叶、颞叶功能显著降低并且与病程和药物治疗无关。提示额。

Objective To evaluate the changes in brain function of patients with anxiety disorders. Methods 53 cases, which were divided into two groups : previously drug treated group and non-drug, were compared with a matched control group of normal volunteers with SPECT to access anxiety -related abnormalities of regional cerebral blood flow(rCBF). Results 92 5 percent of patients had relative hypoperfusions in some cerebral regions. To be compared with control group, both groups of patients shown significant decreases of rCBF in bilateral frontal lobes and temporal lobes and also a hypoperfusion in left basal ganglia of the drug group. There was no significant difference in every region between the two groups of patients. Conclusions Patients with anxiety disorders had profound dysfunctions of the frontal and temporal cortices, the time course of the disease and benzodizepine medications did not affect the alteration of the rCBF. These may reflect a fundamental feature of clinical neuropathophysiology in anxiety disorders.