系统性红斑狼疮尸检临床病理分析

The clinicopathologic study on systemic lupus erythemustosus

目的：本文对３例系统性红斑狼疮（ＳＬＥ）尸检材料进行临床病理分析。探讨ＳＬＥ患者的继发感染和死因。方法：对ＳＬＥ尸检标本进行常规染色，光镜观察。结果：病变主要在肾脏、心内膜和浆膜，其他器官也可受到影响，而狼疮性肾炎是很明显。结论：ＳＬＥ属自身免疫性疾病。继发感染与使用皮质激素和免疫抑制剂有关。肾功衰竭是ＳＬＥ的死亡原因。

Objective:The clinical features and pathological changes of specimens of 3 autopsies of systemic lupus erythematosus (SLE)were studied in the artiele. The secondary infection and the causes of death for the patients with SLE were studied. Method:The specimens of necropsy of SLE were examined by means of routine HE staining and light microscope. Result:The lesions were mainly in the kidney, endocardium, and involved serous membranes, but other organsmay be affected. The lupus nephritis was obvious. Conclusion: SLE belongs to autoimmune disease. The secondary infection relates to the use of corticosteroid and immu- nosuppressive factors. Renal failure is the most important cause of death in SLE.