摘要
为探讨ｐ５３和ｃ－ｍｙｃ基因异常表达与膀胱癌多药耐药性（ＭＤＲ）的关系，应用ＡＢＣ免疫组织化学方法检测６７例膀胱癌癌细胞中ｐ５３和ｃ－ｍｙｃ的表达产物及多药耐药基因（ｍｄｒ－１）产物Ｐ－ｇｐ。结果显示ｐ５３突变蛋白蓄积的膀胱癌中Ｐ－ｇｐ阳性表达率９２．３％；ｐ５３阴性者Ｐ－ｇｐ阳性率为３６．６％。Ｐ－ｇｐ表达与ｐ５３突变蛋白蓄积呈显著正相关（ｒ＝０．６４，Ｐ＜０．０５）；而ｃ－ｍｙｃ和ｍｄｒ－１的表达无明显相关。提示：ｐ５３异常表达可增加ｍｄｒ－１基因的表达。
In order to study the correlation between abnormal expression of p53 and c myc with multidrug resistance (MDR) in bladder cancer,and by using ABC immunohistochemical methods, the expression products of p53 and c myc and P gp/mdr 1 in 67 cases of bladder cancer was tested. The P gp positive rate of p53 protein accumulation in bladder cancer was 92.3%, while P gp positive rate of p53 negitive was 36.6%. A significant correlation was found between p53 protein accumulation and mdr 1 gene expression ( r =0.64, P <0.05),while there was no correlation between c myc and mdr 1. p53 protein accumulation might increase the expression of mdr 1 gene, and the bladder cancer cell can get MDR phenotype.
出处
《肿瘤研究与临床》
CAS
1998年第3期145-147,共3页
Cancer Research and Clinic
