肝癌患者癌旁组织DNA倍体、SPF、AFP和病理分级同步检测的临床意义

THE CLINICAL SIGNIFICANCE OF SYNCHRONOUS MEASUREMENT OF DNA PLOIDY AND SPF IN PARA CANCER TISSUE,AFP AND PATHOLOGICAL CLASSIFICATION ON PATIENTS WITH HEPATOCELLULAR CARCINOMA

为探讨肝癌癌旁组织ＤＮＡ倍体、Ｓ期细胞比率（ＳＰＦ）、甲胎蛋白（ＡＦＰ）和病理分级等指标与患者肿瘤恶性度及预后的关系。对４２例肝癌患者癌旁组织倍体和ＳＰＦ、血清ＡＦＰ及肿瘤病理分级进行同步检测。结果显示患者癌旁组织异倍体检出率为５９．５％。癌旁组织倍体、ＳＰＦ、ＡＦＰ和病理分级之间均密切相关。根据患者对４项指标反应的不同分为预后不同的５级。这样，从Ⅰ级至Ⅴ级患者肿瘤恶性度越来越高，预后越来越差。其５ａ生存率和生存期分别为１００％、８５．７％、５５．６％、４４．４％、０和７５．９个月、６５．１个月、４７．４个月、４４．２个月、８７个月。认为肝癌癌旁组织ＤＮＡ倍体、ＳＰＦ。

To study the relationship of tumor malignancy and patient prognosis with DNA ploidy and S phase fraction(SPF) of para cancer tissue,a fetoprotein (AFP) and pathological classification in hepatocellular carcinoma,the DNA ploidy,SPF and pathological classification were measured synchronally on para cancer tissue samples from 42 hepatocellular carcinoma patients. The DNA aneuploidy rate of para cancer tissue was 59.5%. The relationship was closely correlated among DNA ploidy,SPF,AFP and pathological classification. The patients were graded into 5 categories depending up on their reaction to the 4 criteria. Thus the malignancy of the tumor gradually increased and prognosis became gradully worse with grade of patients from 1 to 5. The five year survival rate and survival time in each group were 100%,85.7%,55.6%,44.4%,0,and 75.9,65.1,47.4,44.2 and 8.7 months respectively.The above results is helpful for patients' grading and prognosis in hepatocellular carcinoma.