血液流变学在胃癌TNM分期中的意义

Significance of hemorrheology in classifying gastric cancer TNM

目的检测胃癌患者血粘度的变化，寻找早期发现胃癌的简易指标。方法：检测４４例胃癌患者血液流变学（血粘度）的有关指标，并按国际ＴＮＭ法分组，分析各血液流变学指标在胃癌不同分期中的意义。结果：（１）胃癌患者的全血低切粘度比正常人增高３０％，血浆高切粘度增高１１０．８％，红细胞凝聚指数增加４８．１８％，红细胞刚性指数增加５２．９４％；而红细胞变形指数明显低于正常人４８．９４％。各项比较均有显著性差异（Ｐ＜０．０５）。（２）按国际ＴＮＭ分期将各患者分组后表明：在Ⅰａ－Ⅱ期间，随着胃癌分期的增加，全血低切粘度、全血高切粘度、血浆高切粘度、红细胞凝集指数、红细胞刚性指数、全血还原粘度指标逐渐增加；红细胞变形指数逐渐降低；Ⅲ－Ⅵ期患者表现为红细胞刚性指数增加和红细胞变形指数下降，而其它指标却接近正常。结论：当机体的血液流变学指标发生改变时，应引起高度重视。

Obiective: To check the hemorrheological value in the patients with stomach cancer Methods:We checked the hemorrheological value in 44 patients with gastric cancer, divided into groups by international TNM assay,and analyzed their significance.Results:In these patients,the blood low shear viscosity was increased 30%,the plasma high shear viscosity was increased 110.85%,the RBC agglutination increased 48.18%,the RBC rigidity increased 52.94%,but the RBC deformation decreased 48.94%.In accordance with international TNM criteria,the results showed that during Ia to Ⅱ stages,the blood low shear viscosity,high plasma shear viscosity,the RBC agglutination,and RBC rigidity were gradually increased,but the RBC deformation was gradually decreased.In Ⅲ-Ⅳ stage patients,the rate of RBC rigidity increased,the RBC deformation rate decreased and the other parameters were nearly normal.Conclusion:Much attention should be paid to the patient with changes of hemorrheological parameters.