血清荧光光谱对肺癌诊断的临床意义

Clinical significance of serum fluorescent spectrum in diagnosing early lung cancers

肺癌发病率和死亡率呈逐年上升趋势、５年生存率仅１０％左右。肺癌的早期诊断有重要意义。笔者应用荧光对１１０例肺癌患者、１００例肺良性疾病患者和３５例正常人的血清进行检测。分析其荧光光谱。以波长６２５ｎｍ处的荧光强度大于波长６１５ｎｍ处为阳性，小于者为阴性，肺癌组阳性７７例（７０％），肺良性疾病组阳性１６例（１６％），健康对照组２例（５．７１％）阳性，肺癌组阳性率明显高于肺良性疾病组（Ｐ＜０．０１）和健康对照组（Ｐ＜０．０１）；不同组织类型的肺癌阳性率不同、腺癌阳性率最高８７．８８％，鳞癌次之６７．６５％，小细胞癌５０％。上述结果表明，应用荧光光谱分析对肺癌（尤其是非小细胞肺癌）的诊断，甚至早期诊断有重要参考价值。

Objective:To find out an early diagnostic method for lung cancer.Methods:fluorescent spectrum was used to assay the serum of 110 patients with lung cancer, 100 patients with benign lung diseases and 35 normal persons were used as controls.Those fluorecence intensities in 625 nm being higher or lower than in 615 nm are defined as positive or negative respectively.Results:The number of positiveness was 77 in lung cancer group.6 in 10 patients with early stage lung cancer;16 in benign lung disease group (six in pulmonary tuberculosis),and 2 in normal persons.The positive rate in lung cancer group was much higher than that in benign lung disease group(P<0.01)and normal person group(P<0.01),and also higher than that of pulmonary tuberculosis group(P<0.01),Different positive rate had different histologic types of lung cancer,the highest positive rate being adenocarcinoma(87.84%),the second, squamous cell cancer (71.43%),and the lowest, small cell cancer(61.11%).Conclusion:It shows from above resultes that there is of important referential value in using the analysis of fluorescent spectrum in the early diagnosis of the lung cancer, especially for nonsmall cell lung cancer.