静脉输注脂肪乳剂对糖尿病病人代谢的影响

Effect of intravenous fat emulsion on the metabolism of non insulin dependent diabetes

目的：观察非胰岛素依赖型糖尿病病人输注脂肪乳剂后糖、脂代谢改变。方法：３８例ＮＩＤＤＭ病人被随机分为伍用正规胰岛素组及伍用口服磺脲类降糖药组，每天输入１０％脂肪乳剂５００ｍｌ连续５天。结果：ＦＢＳ、ＨＤＬ、ＡｐｏＡ，在两组均未有改变；血清ＴＧ在口服药组升高（Ｐ＜０．０１），Ｃｈ在两组均显著升高（Ｐ＜０．００１）；加用胰岛素可明显促进肝脏短半衰期蛋白质（ＰＡ、ＴＦ）合成（Ｐ＜０．０５）。结论：对稳定型ＮＩＤＤＭ病人使用脂肪乳剂是安全的，加用胰岛素可避免高ＴＧ血症。

Objectives:To study the metabolic chages in NIDDM patients after intravenous fat emulsion. Methods:Thirty eight NIDDM patients were randomly divided into insulin group and oral sulfonylureas group.10% fat emulsion 500 ml was given per day for five days. Results:FBS,HDL,ApoA 1 were unchanged in both two groups.Serum triglyceride was increased in oral sulfonylureas group and serum cholesterol was significantly elevated in both two groups.Heptic synthesis of prealbumin and transferrin was remarkably promoted by administration of fat emulsion in insulin group. Conclusions:Intravenous fat emulsion was safe in stable diabetes patients and insulin could prevent the hypertriglyceridemia.