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^(99m)Tc-DTPA测定肠道通透性的方法及应用 被引量:15

The test method of intestinal permeability by measuring 99m Tc DTPA and its application
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摘要 目的:建立99m锝┐乙三胺五乙酸(99mTc┐DTPA)测定肠道通透性的方法并观察其在临床和动物实验研究中的应用效果。方法:口服99mTc┐DTPA37~74MBq,收集24h尿液,γ计数器测定尿液中DTPA排泄量。采用此方法观察了9例健康人和25例胃肠道手术病人手术前及术后7天肠道通透性,3组病人术后7天分别给予谷氨酰胺0g/(kg·d)(A组,n=8),0.3g/(kg·d)(B组,n=8)和0.6g/(kg·d)(C组,n=9);10头杂交猪自体小肠移植后分别给予标准全肠外营养(STPN组,n=5)和强化3%甘氨酰谷氨酰胺的全肠外营养(GTPN组,n=5)28天观察移植小肠的通透性。结果:9例健康人24h尿液DTPA排泄率为4.86±1.86%,术后7天A、B二组病人DTPA排泄率较术前明显增加(6.64±3.95%vs13.71±4.85%;8.88±3.95%vs10.76±2.88%,P<0.05),C组手术前后肠道通透性无变化(6.80±2.12%vs3.55±1.29%,P>0.05)。术后28天STPN组DTPA排泄率明显高于GTPN组(24.01±7.44%vs7.77±3.04%,P<? Objectives:To establish the test method of intestinal permeability by measuring urinary recovery following oral administration 99m Tc DTPA and estimate its application. Methods:The subjects were given 37 ̄74 MBq 99m Tc DTPA in 1ml of water.Urine was collected for 24 h.The samples were counted in a Gamma counter.Twenty five patients underwent gastrointestinal surgery were divided into 3 groups.The patients were given intravenously 0(group A, n =8),0.3(group B, n =8) and 0.6g/(kg·d)(group C, n =9) of glutamine for 7 days after operation.Ten outbred pigs underwent small bowel autotransplantation were divided into 2 group.The animal received standard total parenteral nutrition(STPN group) and glycyl glutamine enriched TPN(GTPN group) for 28 days.The intestinal permeability was investigated by measuring the urinary excretion of 99m Tc DTPA. Results:Urine excretion in 9 health subjects was 4.86±1.56%,urine excretion of DTPA in group A and group B was significant increase on the postoperative 7 day(6.64±3.95% vs 13.7±4.85% in grouop A,8.88±3.95% vs 10.76±2.28% in group B, P <0.05).No difference were observed in group C(6.80±2.12% vs 3.55±1.29%).On the postoperative 28 day,the urinary excretion of DTPA was significant high in STPN group compared with GTPN group(24.01±7.44% vs 7.77±3.04%, P <0.01). Conclusion:Urinary excretion of 99m Tc DTPA is a simple test that measure accurately the intestinal permeability.The test may be recommended as intestinal permeability test for use in clinical and experimental practice.
出处 《肠外与肠内营养》 CAS 1998年第4期227-229,共3页 Parenteral & Enteral Nutrition
关键词 肠道通透性 锝99M DTPA 测定 m Tc DTPA Intestinal permeability
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