摘要
为探讨红细胞膜Na+-K+-ATP酶活性与动脉硬化性脑梗塞的关系，本文检测了37例动脉硬化性脑梗塞患者、20例脑动脉硬化症患者和25例健康对照者的红细胞膜Na+-K+-ATP酶活性，并将酶活性与脑CT梗塞灶大小进行直线回归分析。结果发现，动脉硬化性脑梗塞和脑动脉硬化症患者的Na+-K+-ATP酶活性明显降低，酶活性降低程度与脑CT梗塞灶大小呈显著负相关性（r=-0．58,P＜0．01）。提示：红细胞膜Na+-K+-ATP酶活性降低在动脉硬化性脑梗塞的发病与发展中具有一定作用，它可能是脑梗塞的一个危险因素。
To study the correlation between the activity of Na+-K+ -ATPase on erythrocyte membrane and arteriosclerotic cerebral infarction. Activity of Na+-K+ -ATPase on erythrocyte membrane was determined in 37 cases of arteriosclerotic cerebral infarction (ACI)and 25 normal control subjects. Activity of Na+ -K+-ATPase on erythrocyte membrane in ACI was obviously lower than that of control (P<0. 001), and the activity of Na+ -K+ -ATPase on erythrocyte membrane was negative correlated with infarct size on brain CT scans in ACI(r= -0. 58, P<0. 01).It suggested that the reduced activity of Na+ -K +-ATPase on erythrocyte membrane may have some ef-fect in the development of ACI.
出处
《中国动脉硬化杂志》
CAS
CSCD
1998年第3期243-245,共3页
Chinese Journal of Arteriosclerosis
关键词
脑梗塞
脑动脉硬化症
红细胞
ATP酶
Cerebral infarction
Cerebral arte-riosclerosis
Erythrocyte
Na +-K+- ATPase
