慢性肾功能衰竭患者血脂质变化

Changes of Lipid Profile in Chronic Renal Failure Patients

为研究慢性肾功能衰竭患者血脂质变化，检测40例慢性肾功能衰竭患者血清甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白AI和B水平。结果显示，慢性肾功能衰竭患者血清甘油三酯及载脂蛋白B较对照组明显升高（1．27±0．60mmol／L比0．79±0．23mmol／L，P＜0．01；0．89±0．18g／L比0．80±0．17g／L，P＜0．05）；高密度脂蛋白胆固醇、载脂蛋白AI和载脂蛋白AI／B比值均明显降低（分别为1．07±0．47mmol／L比1．41±0．29mmol／L；1．26±0．28g／L比1．46±0．10g／L；1．41比1．82，P均＜0．01）。以上提示，慢性肾功能衰竭患者脂质代谢紊乱主要表现为甘油三酯和载脂蛋白B浓度升高，高密度脂蛋白胆固醇和载脂蛋白AI浓度降低。

Aim To analyze the lipid profile changes in chronicrenal failure patients.Methods Forty cases of chronic renal failure patients were studied. Triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC).apolipoprotein AI (Apo AI) and apolipoprotein B (ApoB) were assessed.Results The values of TG, Apo B were higher andvalues of HDLC, Apo AI, Apo AI/Apo B were lowerin chronic renal failure patients compared with control group. The values of TC and LDLC, however, were no different from that values in the control group.Conclusion Lipids abnormorlities were present in some chronic renal failure patients.