用高价人抗HBs在人体内诱导产生抗HBs

The Induction of the Production of Anti-Hbs Antibodies in Human by Injecting Human Anti-HBs Antibodies

本文探讨用外源性人抗HBs在人体通过免疫网络诱导产生自身的抗HBs的可能性。志愿者经多次注射人高价抗HBs(Ab_1)后,体内产生了Ab_2,进而产生出特异性与Ab_1相同的Ab_3;当Ab_3水平升高时,Ab_2水平下降。此结果证实了人体内独特型网络的存在及其活跃的调节功能,表明用于被动免疫的人抗HBs在人体也能通过激活独特型网络产生主动免疫保护作用。此外,本文的结果还提示,注射人抗HBs后,人体内产生的Ab_2可模拟HBsAg,使常规的HBsAg检查出现假阳性结果。

It is described that the study on the anti-HBsAb in human body were inducted by injecting human anti-HBs. 20 volunteers were repeatedly injected with varying doses of human anti-HBsAb(Abl),and productions of Ab2 and Ab3 in sera were continuously detected with ELISA. It was found that in humanbody exogenous human anti-HBs (Ab1) induced productions of Ab2, Ab3 level rised while Ab2 level droped, then Ab3 which was the same in specificity as Abl . These results clearly indicate the existence and active function of idiotype network in humanbody, and demonstrate that human anti-HBsAb used in apssive immunity can also bring about active immunity in human beings by activation of idiotype network.In addition, our results suggest that Ab2 induced by human anti-HBsAB injected into humanbody may mimic HBsAg, resulting in a psuedoreaction in the routine examination of HBsAg.