三唑类化合物的合成及其抗真菌活性Ⅰ

Synthesis and Antifungal Activity of Triazole DerivativesⅠ

根据氮唑类抗真菌药物的作用机理及构效关系，设计合成了１５个１（１Ｈ１，２，４，三唑１基）２（２，４二氟苯基）３取代苯氧基２丙醇类化合物，其结构经氢核磁共振谱证实．初步体外抑菌实验表明：该类化合物对常见深部致病真菌如白念珠菌、新生隐球菌、申克氏孢子丝菌、卡氏枝孢霉菌均有一定程度的抗菌活性．化合物（Ｉ２），（Ｉ９）的体外活性优于氟康唑。

According to the antifungal mechanisms and structure activity relationships of the azole compounds,fifteen 1 (1 H 1,2,4 triazole 1 yl) 2 (2,4 difluorophenyl) 3 substituted phenoxy 2 propanols were designed and synthesized.All of them were confirmed by 1H NMR and elementary analysis.The results of the preliminary antifungal tests in vitro showed that all of the title compounds exhibited mild activities against systematic pathogenic fungi such as Candida albicans,Cryptococcus neoforms,Sporotrichum schenckii and Cladosporium carrionii.