精神分裂症患者及其健康同胞脑白质密度研究

Study of White Matter Density in Schizophrenic Patients and Their Healthy Siblings

目的:观察精神分裂症患者及其健康同胞脑白质密度的特点。方法:用基于像素的形态学测量法比较三组的白质密度。结果:在左侧前额叶和胼胝体膝部,患者及同胞的白质密度值显著小于正常对照组,患者和同胞之间的差异未达到统计学意义水平。结论:左侧前额叶和胼胝体膝部白质密度值降低可能与精神分裂症的患病风险有关。

Objective： To determine the white matter density in schizophrenia patients and their healthy siblings compared with healthy controls. Methods： White matter density was compared among three groups by voxel-based morphometry. Results： White matter density in the left prefrontal cortex and genu of corpus callosum was significantly reduced in both patients and their siblings compared with that in controls. Conclusion： Reduced white matter density in left prefrontal and genu of corpus callosum may be related to the risk of schizophrenia.