血浆同型半胱氨酸水平与血管性痴呆的关系

Relationship Between Vascular Dementia and Plasma Homocysteine Level

目的:探讨血浆同型半胱氨酸(Hcy)、血清叶酸和维生素B12水平与血管性痴呆(VD)的关系。方法:应用反相高效液相色谱法(RP-HPLC)测定30例VD患者的血浆Hcy水平,用放射免疫法(RIA)测定其血清叶酸及维生素B12水平,并与58例非痴呆脑梗死患者和30例同龄对照比较。结果:VD组血浆Hcy水平显著高于非痴呆脑梗死组;非痴呆脑梗死组血浆Hcy水平显著高于同龄对照组;VD组血清叶酸水平明显低于非痴呆脑梗死组;非痴呆脑梗死组血清叶酸水平明显低于同龄对照组。结论:Hcy可能是VD发病的一个危险因素。

Objective： To study the relationship between plasma homocysteine （Hcy）, serum folate ,Vitamin B12 levels and Vascular dementia （VD）. Methods： 30 VD patients, 58 patients with uondemented cerebral infarction and 30 normal subjects of the same age were recruited in to the study. Their plasma Hcy levels were measured by reversed phase high performance liquid chromatography （RP-HPLC）, and the levels of serum folate and Vitamin B12 were also determined by radioimmune assay （RIA）. Results： Mean of Plasma homocysteine concentrations were significantly higher in VD group than in the nondemented cerebral infarction group. Which were significantly higher in the noudemented cerebral infarction group than in the normal subjects of the same age. Serum folate levels in the VD group were significantly lower than those in the nondemented cerebral infarction group. Which were significantly lower than those of normal subjects. Conclusion： Hcy may be a new risk factor for the onset of VD.