急性T—B细胞双表型白血病四例并文献复习

Acute T-B cell biphenotypic leukemia： report of four cases with literature review

目的总结急性T—B细胞双表型白血病的临床及实验室特征。方法报道该院诊治的4例及复习文献报道的10例，共14例急性T—B细胞双表型白血病患者资料，总结其临床表现、实验室特征及预后。结果急性T—B细胞双表型白血病以中青年男性相对多见，14例患者中男10例（年龄在17～46岁），临床表现符合急性淋巴细胞白血病的一般特点，该类型白血病对急性淋巴细胞白血病的常规化疗方案反应差，疾病进行性恶化，中位生存期仅10个月，6例患者诊断后12个月内死亡。结论急性T—B细胞双表型白血病极为少见，预后恶劣。提高对该病的认识，制订合适的治疗策略很有必要。

Objective To strengh the awareness of acute T-B cell biphenotypic leukemia. Methods Four new cases of acute T-B cell biphenotypic leukemia were reported and the related literature were reviewed. Results Fourteen patients with acute T-B cell biphenotypic leukemia, including 4 diagnosed at our hospital and other 10 cases reported in literature, were retrospectively analyzed. Similar clinical features as the typical acute lymphocytic leukemia（ALL） were presented. Ten of 14 cases were male and were within 17 to 46 years old. The disease were refractory to the conventional ALL chemotherapy regimens and deteriorated progressively. Six patients died within 12 months after their diagnosed with the median survival time of ten months. Conclusion Acute T-B cell biphenotypic leukemia is one of the most rare type of leukemia. A better understanding of the clinical and hematological features of this type of leukemia and new therapeutic strategies are needed.