独立生长因子1B在常见血液病中的研究进展

Advance of growth factor-independent 1B（GFI1B） in common hematologic diseases

近来研究显示独立生长因子1B（GFI1B）基因主要在胎儿、成年人的红系及巨核系表达。2006年国外首次报道了GFI1B在急性白血病中呈高水平表达，尤其是在急性髓系白血病（AML）-M6和M7的患者中表达显著增高。这为临床诊断及鉴别诊断AML亚型提供了重要理论依据。将GFI1B基因在白血病、T细胞淋巴瘤、骨髓增生异常综合征（MDS）等血液病中的表达情况及研究进展进行综述。

Recent studies have demonstrated that GFI1B is most prominently expressed in cells of the fetal and adult erythroid and megakaryocytic lineages. In 2006, it is first reported that GFI1B is highly expressed in acute myeloid leukemia, especially in erythroleukaemia and megakaryocytic leukaemia. This report provides theoretical basis for diagnosis and differential diagnosis of subtypes of acute myeloid leukaemia. In this review, we covered the expression of GFI1B in leukemia, T-cell lymphoma, myelodysplastic syndrome and so on.