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T细胞受体重排删除环检测在异基因造血干细胞移植中的应用

Application of T cell receptor rearrangement excision circles expression in allogeneic hematopoietic stem cell transplantation
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摘要 异基因造血干细胞移植是治疗血液肿瘤和免疫疾病的重要手段，免疫功能重建是评估移植疗效的重要因素，T细胞受体重排删除环（TREC）作为胸腺近期输出功能的标志广泛用于评价健康人和造血干细胞移植、血液肿瘤、HIV感染和自身免疫性疾病等的胸腺输出功能。 Allogeneic hematopoietic stem cell transplantation （allo-HSCT） represents a potentially curative treatment modality in a range of hematologic malignancies and autoimmune disease. Immune reconstitution is a major factor to evaluate the outcome of transplantation. As markers for recent thymie output function, T cell receptor excision circles（TRECs） have been widely applied to evaluate thymic output function in normal individuals or in patients with hematopoietie stem eell transplantation, hematologic malignancies, HIV infection or autoimmune disease.
作者 吴巨峰(综述) 李扬秋(审校)
机构地区 海南省人民医院血液内科 暨南大学医学院血液病研究所
出处 《白血病．淋巴瘤》 CAS 2009年第12期763-765,共3页 Journal of Leukemia & Lymphoma
基金 海南省自然科学基金（30520）
关键词 受体 抗原 T细胞 造血干细胞移植 Receptors, antigen, T-cell Hematopoietic stem cell transplantation
分类号 R457.7 [医药卫生—治疗学] R392 [医药卫生—免疫学]
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参考文献26

  • 1Poulin JF, Sylvestre M, Champagne P, et al. Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease. Blood, 2003, 102: 4600-4607.
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二级参考文献23

  • 1[1]Hazenberg MD, Verschuren MC, Hamann D, et al. T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med, 2001; 79:631-640
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  • 7[7]AL-Harthi L, Marchetti G, Steffens CM, et al. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymersse chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). J Immunol Medthods, 2000; 237:187 - 197
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共引文献23

白血病．淋巴瘤
2009年 第12期

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