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生长抑素对重症急性胰腺炎的炎性调控作用 被引量：17

Effect of somatostatin on inflammation in acute hemorrhagic necrotizing pancreatitis
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摘要 目的:探讨生长抑素对大鼠重症急性胰腺炎(SAP)时炎性调控作用及其机制。方法:逆行胰胆管注射牛磺胆酸钠(TAC)制备SAP模型。动物分为假手术组(SO组),生理盐水处理组(SAP组)和奥曲肽治疗组。各组动物术后3、6、12 h剖杀,检测肝组织中Toll-样受体(TLR)24 mRNA和细胞核转录因子(NF-κB)的表达情况。结果:与SO组比较,胰腺炎组大鼠TLR2,4 mRNA于3 h开始升高,于12 h达高峰(P均<0.01);肝组织中NF-κB于3 h开始表达增强,6 h达高峰。治疗组肝组织中的TLR2,4 mRNA及NF-κB各时点表达均降低(P<0.05)。结论:生长抑素对SAP时炎症反应有调控作用。其机制可能与抑制Toll受体和NF-κB表达,降低瀑链式炎症反应有关。 Objective：To observe the effects and mechanisms of somatostatin on the control of inflammation in severe acute pancreatitis. Method：SAP model of rats was made with retrograde injection of artificial bile into the biliary-pancreatic duct. The rats were divided into control group and treating group which received injection of saline or Octreotide. Expressions of TLR2,TLR4 and NF-kB in the liver tissue were detected. Result：TLR2,4 mRNA in liver：in the SAP rised at 3 h,peaked at 12h（ P均〈0.01）;NF-kB expression in liver also rise at 3 h,but peaked at 6h. Treated with Somatostatin, the TLR2,4 mRNA and NF-kB expression in the liver decreased（ P〈0.05）. Conclusion：Somatostatin may inhibit the effects of the elastase and decrease TLR2,TLR4 mRNA and NF- kB expression.
作者 张昭 王丹 赵刚
机构地区 天津市人民医院胰腺外科 天津医科大学附属总医院病理科 华中科技大学同济医学院附属协和医院胰腺外科中心
出处 《临床急诊杂志》 CAS 2009年第6期336-338,341,共4页 Journal of Clinical Emergency
关键词 胰腺炎 急性坏死性 肝/病理学 生长抑素 reseptor,toll acute pancreatis live somatostatin NF-kB
分类号 R576 [医药卫生—消化系统]
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参考文献10

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二级参考文献15

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共引文献19

同被引文献134

二级引证文献149

临床急诊杂志
2009年 第6期

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