摘要
目的确定上海地区成人雌马酚代谢表型及雌马酚的生理范围；把握由于大豆异黄酮负荷而产生的雌马酚产生者比例；调查雌马酚表型和食物摄取频率及有关激素间的关系。方法应用现状调查方法，筛选出172名居住在上海市区健康成年男女。填写问卷获得研究对象日常饮食频率，检测研究对象血清获得血液激素浓度，采用HPLC法分析负荷大豆异黄酮前后尿中雌马酚等大豆异黄酮24h排泄量，统计产雌马酚者比例及其与摄食频率和激素的关系。结果负荷前雌马酚生理范围0—33．74μmol／24h，产雌马酚者比例为30．2％，负荷大豆异黄酮后比例提高至53．5％。产雌马酚者与非产雌马酚者之间日常食品摄取频率的差别无统计学意义（P〉0．05）。产Eq者血中游离雌二醇的浓度较非产Eq者低（P〈0．05）。结论在通常膳食条件下，约有1／3上海成人尿液中能检测到雌马酚，但负荷大豆异黄酮后，约有1／2能产生雌马酚。
To investigate the prevalence of equol producers and the physiological range of urinary equol excretion, and also to evaluate relations between equol phenotype and lifestyle and hormone levels among Chinese adults in Shanghai, 90 male and 82 female adults participated in a cross - sectional study and provided twice 24 - hr urine samples on regular diet and after 3 - d soy isoflavone challenge respectively. A health and demographics questionnaire and daily food frequency , and blood collections were completed before the urine collections. Soy isoflavones and their metabolites in urine were measured to determine equol phenotype by HPLC. The physiological range of 24hr urinary equol excretion was 0 -33.74μmol/24hr, and the percentage of the equol producer phenotype was 30. 2% on regular diet and 53.5% after 3 - d soy isoflavone challenge respectively. There was no statistical difference between the equol producers and the equol non -producers about various indexes except the estradiol（P 〈0.05）. There was no statistical difference between the Eq producers and the none - producers about the frequency of food intake in this experiment（ P 〉0.05）. About 1/3 of Chinese adults in Shanghai were detected equol excretion in urine under the usual lifestyle. However,equol - producing potential was higher.
出处
《氨基酸和生物资源》
CAS
2009年第4期46-50,59,共6页
Amino Acids & Biotic Resources
