乙型肝炎患者血清IL-2、IL-6及SIL-2R的检测意义

Detection and significance of serum level of IL-2,IL-6,SIL-2R in hepatitis B patients

本文用酶联免疫吸附实验（Ｅｌｉｓａ）检测了８７例乙型肝炎各型患者及２１例乙肝病毒携带者血清中白细胞介素２（ＩＬ－２）、白细胞介素６（ＩＬ－６）、可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）水平。结果如下：乙型肝炎各型患者及健康携带者的ＩＬ－６水平均明显高于正常对照（Ｐ＜００５）；急性肝炎（ＡＨ）、慢性活动性肝炎（ＣＡＨ）、肝硬化（ＬＣ）、重症肝炎（ＦＨ）血清ＩＬ－２明显低于正常对照（Ｐ＜００５）；ＳＩＬ－２Ｒ则明显高于正常对照（Ｐ＜００５）。结果提示：乙肝患者ＩＬ－２、ＳＩＬ－２Ｒ，ＩＬ－６水平变化可能存在不同机理。

The level of serum IL-2,IL-6,SIL-2R were measured in 87 patients with hepatitis B and 21 HBV carriers by enzyme-linked assay. We found that IL-6 concentration was elevated significantly in each type of hepatitis B patients and HBV carriers,compared with control group(P<005);SIL-2R and IL-2 level in acute hepatitis,chronic active hepatitis,fulminant hepatitis and cirrhosis were different from control significantly (P<005).It indicated that IL-2,Il-6,SIL-2r played different roles in aberration of immunoregulation of HBV infections.