全反式维甲酸治疗APL诱发高白细胞症的临床观察

CLINICAL OBSERVATION OF LEUKOCYTOSIS OCCURRING DURING THE TREATMENT WITH ALL-TRANS RETINOIC ACID FOR ACUTE PROMYELOCYTIC LEUKEMIA

为了提高全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）诱发高白细胞症的疗效，对21例APL在ATRA治疗中出现的高白细胞症进行观察，并用羟基脲或三尖杉酯碱治疗。结果显示：对白细胞上升较迟峰值较低的普通组高白细胞症患者用羟基脲治疗有效，而对白细胞上并迅速且峰值较高的严重组高白细胞症患者用三尖杉酯碱治疗有较好的疗效。

Objectives:To achieve better therapeutic effects in he treatment for leukocytosis occurring during the treatment with all--trans retinoic acid for acute promyelocyticleukemia. Methods: Hydroxyurea or Harringtonine was used in 21 cases of APL duringtreatment with ATRA. Results: The result showed that the use of hydroxyurea to treat patients with a slow increase in WBC and with WBC in low number proved to be effective; andthat the use of harringtonine to treat patients with a rapid increase in WBC and with WBC invery high number proved to be very effective.