环磷酰胺联合雷公藤治疗肾病综合征的临床研究

CLINICAL STUDY OF CYCLOPHOSPHAMIDE AND TRIPTERYGIUM WILFORDII IN TREATING NEPHROTIC SYNDROME

目的观察环磷酰胺（CTX）冲击疗法联合大剂量雷公藤多甙（TⅡ）治疗原发性难治性肾病综合征的疗效。方法治疗组30例，CTX0．5～1．0g／m2静滴，每月一次，连用3—6次后，改为3个月一次，在改为每3个月一次或停药时加用TⅡ2mg／（kg·d），6～8周后逐渐减至维持量；对照组28例单用CTX冲击疗法。两组疗程均为9～12月。结果治疗组完全缓解20例（占66．67％），总有效26例（占86．67％），明显高于对照组（P＜0．05）。结论二药联用可提高疗效。

Objective To determine the therapeutic effects of intravenous cyclophosphamide(CTX) pulse therapy with large dosage of T I (a multiglucoside extract fromTripterygium Wifordii Hook f) on patients with primary and severe nephrotic syndrome(PSNS). Methods 30 cases in the therapeutic group were given tV - CTX intravenousdrip (0. 5- 1.0g/m2 each) once a month in 3- 6 months,then once every three monthsand then at the time of once every three months or at the time of withdrawal,T I (2mg/kg. d) was added for 6-8 weeks. 28 cases in the control group was given only IV-CTXas therapeutic method. All the patients in both groups were treated for 9- 12 months.Results The complete remission rate and total effective rate of the therapeutic groupwere 20 cases (accounting for 66. 67% )and 26 cases (accounting for 86. 67% ) respectively, which were significantly higher as compared with the control group (P<0. 05).Conclusion The combined therapy of both CTX and T Ⅰ can improve the therapeutic effect on patients with PSNS.