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阿托伐他汀对糖尿病大鼠周围神经病变的治疗作用

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摘要 50只正常SD雄性大鼠随机分为①对照组Ⅰ(n=10);②对照组Ⅱ(n=10);③糖尿病模型对照组(n=10);④生理盐水治疗组(n=10);⑤ATV治疗组(ATV,n=10)。结束后行空腹血糖、总胆固醇、坐骨神经传导速度测定。结果:ATV治疗组鼠的坐骨神经传导速度(28.23±1.01 m/s)明显较生理盐水治疗组鼠(15.10±0.90m/s)及糖尿病模型对照组鼠(15.94±0.85m/s)增快。各组治疗前后血糖、总胆固醇相比无明显差异)。结论:ATV可改善STZ大鼠DPN,这种作用不依赖其降脂效应。
出处 《实用糖尿病杂志》 2009年第6期23-24,共2页 Journal of Practical Diabetology
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参考文献6

  • 1L lewelyn JG. The diabetic neuropathies: types, diagnosis and management. J Neurol Neurosurg Psychiatry 2003 ;74:5 -7.
  • 2Kureishi Y, Luo Z, Shiojima I, et al. The HMG - CoA rexiuctase inhibitor simvastatin activates the protein kinase Akt and promotes angiogencsis in normocholestcrolcmic animals. Nat Med 2000; 6 ( 9 ) : 1004 - 1010.
  • 3Robcrtson DM, Sima AA. Diabetic ncuropathy in the mutant mouse [ C57BL/ks ( db/db ) ] : a morphomctric study. Diabetes 1980;29(1) :60 - 67.
  • 4刘芳,周景花,丁巧英,彭名淑,管佩玲,张杰,姚庆姑.高压氧抑制TGF-β1改善STZ糖尿病大鼠周围神经病变[J].复旦学报(医学版),2005,32(4):455-459. 被引量:6
  • 5于德民,吴锐,尹潍,袁咏.实验性链脲佐菌素糖尿病动物模型的研究[J].中国糖尿病杂志,1995,3(2):105-109. 被引量:425
  • 6Robertson DM, Sima AA. Diabetic neuropathy in the mutant mouse [ C57BL/ks ( db/db ) ] : a morphometric study. Diabetes 1980;29( 1 ) :60 - 67.

二级参考文献8

  • 1Vinik AI, Park TS, Stansberry KB, et al. Diabetic neuropathies.Dia-betologia ,2000,43(8) :957
  • 2Chen S, Jim B, Ziyadeh FN. Diabetic nephropathy and transforming growth factor-beta: Transforming our view of glomerulosclerosis and fibrosis build-up. Semin Nephrol, 2003 , 23 ( 6 ) : 532
  • 3Flyvbjerg A. Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease. Diabetologia,2000,43:1205
  • 4Kessler L, Bilbault P, Ortega F, et al. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study. Diabetes Care ,2003,26(8) :2378
  • 5Skundric DS, Lisak RP. Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: from glucose metabolism to neurode generation. Int J Exp Diabesity Res,2003,4(4) :303
  • 6Fife CE,Buyukcakir C, Otto Gtto, et al. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy:a retrospective analysis of 1,144 patients. Wound Repair Regen ,2002,10(4): 198
  • 7赵景礼,丁素菊,崔毅,喻莉,周翠玲,赵楠.高压氧对糖尿病患者周围神经传导速度的影响[J].中华理疗杂志,2001,24(3):147-149. 被引量:18
  • 8李顺勇,杨亚超.高压氧治疗糖尿病周围神经病变的临床观察[J].临床荟萃,2003,18(13):755-756. 被引量:7

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