人工流产妇女白细胞介素8监测临床观察

Abortion women interleukin-8 monitoring clinical significance

目的探讨人工流产妇女体内炎症介质白细胞介素-8(IL-8)水平变化的临床意义。方法术前查阴道分泌物IL-8水平,并行下生殖道感染的检测,以其中一种或以上微生物感染的孕妇200例作为观察组;对照组200例则无以上微生物感染,比较两组术前及用抗生素治疗后IL-8水平变化。结果观察组治疗前IL-8水平明显高于对照组,两组比较有显著性差异(P<0.05);观察组治疗前后IL-8水平呈明显下降,比较差异有显著性意义(P<0.05);而对照组用药前后IL-8水平无明显变化,比较无显著性差异(P>0.05)。结论IL-8可作为人工流产妇女感染的监测指标,当白细胞介素-8(IL-8)水平增高≥174.38ng/L时,人工流产妇女术前应常规行生殖道感染的筛查,为合理处理人工流产、合理使用抗菌素提供科学依据。

Objective： To explore the level changing clinical significance of mediators of inflammation interleukin - 8 inside the women body of induced abortion. Methods ： inspect the level of vagina secretion IL - 8 before operation, and record the inspection of tractus genitalis infection. Make 200 pregnant women with the infection by one or more above microbes as an observation group ; make 200 without the specified infection as a comparison group. Make comparison of the level alteration of IL - 8 before operation , and after treatment of antibiotics. Results ： The observation group is obviously higher than the comparison one in IL - 6 level. The IL - 8 level obviously lowers down in the observation group. Comparison difference is significant （ P 〈 0. 05）. However, the IL - 8 level has no big difference in comparison group. Comparison difference is not big （ P 〉 0.05）. Conclusion ： IL - 8 can be regard as the monitoring index for induced women infection. Induced women should take regular inspection of tractus genitalis infection to provide scientific basis to reasonably handle induced abortion and dose antibiotics, while interleukin- 8 （IL- 8 ） level ≥ 174. 38 ng/L.