雌激素与妊娠期肝内胆汁淤积症发病关系的研究进展

Research on the relationship between the estrogen and intrahepatic cholestasis of pregnancy

妊娠期肝内胆汁淤积症严重影响胎儿健康,是引起围产儿预后不良的主要原因。其发病与雌激素密切相关,目前认为雌激素水平的增高导致胆汁酸代谢异常,大量的胆汁酸在胎盘蓄积,影响胎盘功能从而危及胎儿,是妊娠期肝内胆汁淤积症发病的主要原因,对雌激素合成、代谢、其受体表达及发病机制的研究有助于妊娠期肝内胆汁淤积症的预防、预测及治疗。

Intrahepatic cholestasis of pregnancy （ICP） influences the health of fetus heavily, which is the main cause of perinatal unfavorable prognosis. Its pathogenesy has a closely relations with estrogen. It was considered that the high estrogen level can cause abnormal metabolism of bile acid, so excess bile acid accumulated in placenta can affect placental function and meanwhile endanger fetus. That is the main etiologic factors of ICE. So research on synthesis, metabolism, receptors expression of estrogen and the pathogenesis of ICP can contributes to prevention, prediction and treatment.