三氧化二砷抗肿瘤机制的研究进展

Anti-tumor mechanisms of arsenic trioxide

近年来,三氧化二砷在白血病等各种恶性肿瘤治疗的基础研究和临床实践方面已取得了长足的进步。本文从其诱导肿瘤细胞凋亡、对癌细胞的靶向作用、对抑癌基因的去甲基化作用以及抑制肿瘤细胞生长和肿瘤新生血管形成等方面对三氧化二砷抗癌作用机制的研究进展进行综述。

At present a great progress has made in fundamental research and clinical practice of treatment of leukemia and other cancers by arsenic trioxide. In this review we will focus antiturnous mechanisms of arsenic trioxide on inducing apoptosis in malignant tumor or cell, targeting certain kinds of cancer ceils, inducing demethylation of tumor suppressor genes and inhibiting tumor cell growth and neovascularity.