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胰岛素抵抗不能影响社区HIV/HCV感染者的持续病毒学应答 被引量:3

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摘要 为评价胰岛素抵抗对持续病毒学应答的影响,从接受聚乙二醇干扰素和利巴韦林联合治疗的HIV/HCV合并感染者中选择155名研究对象进行多中心队列研究,主要的结果变量是持续病毒学应答。研究结果显示:55名患者获得持续病毒学应答,其中42名胰岛素抵抗指数小于4的患者获得持续病毒学应答,13名HOMA>4的患者获得持续病毒学应答,但无统计学差异(P=0.27)。对基因1型和4型感染者分析结果显示:HOMA<4和>4的患者的持续病毒学应答无统计学差异(P=0.8)。多变量分析结果显示:基因3型、基线HCV病毒载量和基线LDL胆固醇水平能够影响HIV/HCV合并感染者的持续病毒学应答,而胰岛素抵抗对持续病毒学应答无影响。
出处 《国外医学(医学地理分册)》 CAS 2009年第4期217-220,共4页 Foreign Medical Sciences:Section of Medgeography
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