孟鲁司特钠对成人哮喘患者心理情绪的影响

Psychological effects of montelukast in the adult with asthma

目的:观察孟鲁司特钠对成人轻至中度支气管哮喘患者的心理情绪影响。方法:将44例临床诊断为支气管哮喘的患者随机分为2组,观察组每晚睡前使用孟鲁司特钠10mg;对照组早晚各一次应用酮替芬1 mg。比较2组惠者用药前后临床疗效及心理情绪的变化。结果:对照组与观察组相比,平均每周哮喘发作次数,夜间憋醒次数,焦虑评分,抑郁评分均有明显改善,差异有显著性(P<0.05)。结论:孟鲁司特能有效控制哮喘症状,减轻患者的不良心理情绪影响。

OBJECTIVE To observe the psychological effects of montelukast in the adult patients suffering from mild to moderate asthma. METHODS The 44 cases of adult asthma patients were divided into two groups randomly, the experimental group was treated with oral montelukast 10 mg before the sleep at every night. The control group was treated with oral ketotifen 1 mg at every morning and night. Before and after experiment, the changes of asthma symptom scores in daytime and night- time, the times of nighttime awakening and the uses of inhaled 132 agonist were observed,the psychological status was surveyed with the hospital anxiety and depression score. RESULTS Montelukast significantly improved the clinical symptom and decreased the anxiety and depression scores. CONCLUSION Montelukast can effectively improve asthma symptom,lessen the adverse psychological response.