老年COPD稳定期患者IL-6、IL-8、hs-CRP水平与吸烟关系的探讨

Relationship of IL-6,IL-8,hs-CRP levels and Smoking in Elderly Patients of COPD with stable stage

目的:探讨慢性阻塞性肺疾病(COPD)患者白细胞介素6(IL-6)、白细胞介素8(IL-8)及超敏C反应蛋白(hs-CRP)水平与吸烟的关系。方法:病例组选择老年男性COPD稳定期患者80例,均为吸烟者,检测IL-6、IL-8、hs-CRP水平,据吸烟指数不同及戒烟时间长短分组比较;健康组为门诊健康查体者30例,均为男性,吸烟者与非吸烟者各15例,检测IL-6、IL-8、hs-CRP水平交比较。结果:IL-6、IL-8、hs-CRP水平及吸烟明显相关:健康组吸烟者与不吸烟者相比,IL-6、IL-8、hs-CRP水平明显增高(P<0.05);病例组IL-6、IL-8、hs-CRP水平进一步增高,且与吸烟指数呈正相关,与戒烟时间呈负相关,均有统计学意义(P<0.05)。结论:吸烟与hs-CRP、IL-6、IL-8水平有显著关系(P<0.05);吸烟在促进COPD患者hs-CRP的产生、加快气道炎症的进展中起着重要的作用。

Objective.- To confer chronic obstructive pulmonary disease （COPE）） patients with IL- 6 （IL- 6）, interleukin- 8 （IL -8） and high-sensitivity C-reactive protein （hs-CRP） levels and the relationship between smoking. Methods： Inciude in case group elderly patients with stable COPD male 80 cases, all smokers, to detect IL-6, IL-8, hs-CRP level, as far as to quit smoking index and the length of different sub-comparison; health group healthy patient, 30 cases wer male, smokers and non- smokers of the 15 cases to detect IL-6, IL-8, hs-CRP level and compared. The results of IL-6, IL-8, hs-cRP levels sig- nificantly correlated with smoking： a healthy group of smokers compared with non-smokers, IL-6, IL-8, hs-CRP levels were significantly higher（P〈0. 05） ; patients IL-6, IL-8, hs-CRP levels further increased, and with the smoking index was positively correlated with time to quit smoking was a negative correlation, there was statistical significance （P〈0. 05）. Conclu- sion： Smoking and hs-CRP, IL-6, IL-8 level was significant relationship （P〈0. 05-）; smoking patients with COPD in the promotion of IL-6, IL-8, hs-CRP production, speed up the airway the progress of inflammation might play an important role.