开同对维持性血液透析患者营养状况影响的观察

Effects of Ketosreril on Nutritional status in Hemodialysis Patients

目的:研究开同对改善维持性血液透析患者营养状况的有效性,观察开同对维持性血液透析患者相关营养指标血清白蛋白(ALB)、前白蛋白(PA)、转铁蛋白(TF)、血红蛋白(Hb)、胆固醇(TC)、甘油三酯(TG)的影响。方法:选择60例血液透析患者,随机分为治疗组30例和对照组30例,同时选择30例体检健康者为健康对照组。在常规血液透析基础上,治疗组口服开同(a-酮酸)0.12g/(kg。d),对照组无治疗,总观察期20周。分别在实验开始及20周检测患者血清白蛋白、前白蛋白、转铁蛋白、血红蛋白、胆固醇、甘油三酯浓度。结果:与正常人比较,治疗前维持性血液透析患者的TG、TC水平显著升高(P<0.05),ALB、PALB、Hb显著降低(P<0.05),20周后治疗组与对照组相比,差异有显著性P<0.05和P<0.05,治疗组血清白蛋白、前白蛋白、转铁蛋白、血红蛋白均显著升高,胆固醇、甘油三酯明显降低。结论:开同可有效改善维持性血液透析患者的营养状况。

Objective： To investigate the effect of ketosreril on albumin, pro-albumin, transferrin, hemoglobin cholesteral ,triglyceride in maintenance hemodialysis patients. Methods： sisxy patients undergoing maintenance hemodialysia were randomly divided into therapy group （30patients） and control group（30patients）, 30 healthy people as the normal control group, ketosreril was administered 0. 12g/（ug. d） for 20 weeks. Some serum examination which included total albumin , pro-albumin, transferrin, hemoglobin,cholesteral , triglyceride were performend in the patients before and after 20 weeks treatment. Results： Compared with the normal control group, the concentrations of cholesteral , triglyceride in patients of therapy group and control group before ketosreril treatment were much higher than these in normal control, and the meanwhile the concentrations of albumin , pro-albumin,transferrin,hemoglobin were significantly lower than those in normal control group, after treatment with ketosreril for 20 weeks, Compared with the control group, the albumin , pro-albumin, transferrin, hemoglobin increased significantly in therapy group and the cholesteral , triglyceride decreased significantly. Conclusion： The nutritional status o.f maintenance hemodialysis patients could be improved after ketosreril treatment.